Five cases of severe HBT were detected among 306 patients submitted to videolaryngoscopy over a period of 2 years, corresponding to 1.6% (5/306) of the total sample studied. Three patients are alive with disease and 2 are alive without disease. Three out of four cases had a high Ki-67 index. or a reactive lymphoid proliferation to an unknown antigenic stimulation [2]. Article 2, pp. 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. 1970 Dec;8(3):413-24. Unable to load your collection due to an error, Unable to load your delegates due to an error. The biological behaviours that are exclusive to the tongue base are not clear. 1991 Jul;86(7):801-8. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in Then he looked down my throat through my nose. Imaging examination and tissue biopsy should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes. When we think of hyperplasia, we think of excessive tissue growth. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Am J Dermatopathol. https://doi.org/10.1159/000278291. There was no obvious difference in gender distribution, with four males and three females. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female Tumour cells expressed CD3, CD4, and CD5. It has been historically referred to as reactive lymphoid hyperplasia or pseudolymphoma [1]. Oral Surg Oral Med Oral Pathol Oral Radiol. government site. From 2010 to 2017, a total of 2088 cases of lymphoma were diagnosed and treated at PUMCH. For NHL of the head and neck, there is a logarithmic increase in incidence with increasing age [18] .The average age at disease diagnosis was 61.8years and there were no observed gender differences. A. Kolokotronis, I. Dimitrakopoulos, and A. Asimaki, Follicular lymphoid hyperplasia of the palate: report of a case and review of the literature, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. Four were staged at III and IV and had higher IPI scores (2 or 3). The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. Pseudotumours of the oropharynx due to muscular contraction. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. The cortex is also divided into outer cortex and inner cortex (also known as the paracortex). M Gromet, M J Homer, B L Carter Published Online: Sep 1 1982 https://doi.org/10.1148/radiology.144.4.7111732 PDF Share Article History Published in print: 1982 Figures References Related Details Vol. 2009 Mar-Apr;75(2):195-9. doi: 10.1016/s1808-8694(15)30778-3. The same study also showed that lymphoma at this site is always early stage [21, 24]. https://doi.org/10.1080/02841860500531682. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). https://doi.org/10.4103/0973-1482.136024. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. XS and QL did the HPV ISH. 2010;77:96105. Baran et al. Increasingly, cancers at the base of the tongue are . Do foreign bodies migrate through the body towards the heart? Patricia Uherova et al. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. By using our website, you consent to our use of cookies. Spontaneous regression has also been reported. Chi HS, Lee KW, Chiang FY, Tai CF, Wang LF, Yang SF, Lin SF, Kuo WR. Takahashi H, Fujita S, Okabe H, Tsuda N, Tezuka F. Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity. Ear Nose Throat J. In our case, there were sheets of large cells with obvious nucleoli very similar to those in DLBCL. Would you like email updates of new search results? Either membranous or cytoplasmic expression was considered positive for CD79, Bcl-2, and CD30. https://doi.org/10.1097/01.dad.0000246949.49071.17. Discussions concentrating on NHL of the base of the tongue have focused on the histopathology and lack details regarding progress in the treatment response and prognosis. St. Louis, MO: Elsevier; 2017. Vose JM. The tumour cell composition of MCL varies greatly in the literature, from small cells with slightly irregular nuclei to large cells similar to the large cells in DLBCL, which could be misdiagnosed as DLBCL. The HPV subtype that often infected the cervix, were active but doesnt do much harm to the host because the oral area was not the best breeding site for the virus. We conclude that the frequency of hypertrophied follicles is increased in the presence of signs and symptoms of GER and those HBT symptoms are confused with those of GER, except for nasal voice and noisy respiration. In the literature, findings of RLH are well-documented. The study utilized immunochemistry, in situ hybridization (ISH), and gene rearrangement to confirm the disease and and performed a clinical follow up for each case. M. Samoszuk, E. Ramzi, and J. Ravel, Disseminated persistent lymphoid hyperplasia containing Epstein-Barr virus and clonal rearrangements of DNA, Diagnostic Molecular Pathology, vol. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. Ekstrom-Smedby K. Epidemiology and etiology of non-Hodgkin lymphoma--a review. https://doi.org/10.1016/j.leukres.2005.11.004. 2013;119:18327. Six of the cases exhibited tongue base masses with smooth surface membranes. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. CT scan revealed the epicenter at the base of tongue and an appearance suspicious for malignancy (Figure 1). The diagnosis of FLH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and histopathology. Bookshelf 1),and two cases expressed c-Myc(>40%). 2001;23:54758. The HPV ISH positive case also had diffuse and strong expression of P16 protein as revealed by IHC, besides, HPV RNA ISH in this case is negative (Fig. The remaining five patients were alive through the end of follow up. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. Most lymphomas of the tongue base manifest as an endogenous mass without membranous change. Cut-off values were set as previously described [9]. At the time of manuscript preparation, there were only four articles indexed in Medline that described PTCL and tongue involvement (Table 4, [12,13,14,15]). Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. Ann Oncol. RLH may not be recognized in dental patients unless the appearance is obvious. CAS https://doi.org/10.1007/978-3-319-22822-8_13. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. 2005;9:34050. Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. Reported cases involve the conjunctiva, liver, gastrointestinal tract, stomach, lungs, paranasal sinuses, and many cutaneous areas. P16 stains the nucleolus and cytoplasm. f. Ki-67 staining of the tumour cells (200x). 2011;24:98392. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. In the study of Eisuke et al., hypermethylation of the p16 promotor indicated a poor prognosis [35]. 2017;30:S4453. The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. PubMedGoogle Scholar. There were no c-Myc rearrangements, so there were no double or triple hit B cell lymphomas in these cases (Table3). 96, no. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. His CT and MRI scans found only thickness of the oropharyngeal wall and epiglottal folds, and a superficial biopsy revealed only inflammation. Aguilera NS, Uusafr M, Wenig BM, Abbondanzo SL. e. Tumour cells were positive for Cyclin D1 (200x). Clipboard, Search History, and several other advanced features are temporarily unavailable. 2, no. Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. Another reason might be HPV is not transcriptionally active in this patient; the virus integrated into the host DNA and remained inactive. https://doi.org/10.1007/s12185-008-0142-z. 2014;3:731. https://doi.org/10.1186/2193-1801-3-731. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Primary extra-nodal non-Hodgkin's lymphoma of the cheek. The objective of the present study was to identify severe HBT cases and their symptoms and to correlate them with the presence of pharyngolaryngeal signs and esophageal symptoms of gastroesophageal reflux (GER) in patients seen at a laryngology clinic. 2012;87:6049. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. However, HPV infections have been identified with increasing frequency in patients with oropharyngeal squamous cell carcinoma, which is a predisposing risk factor [29]. In contrast, they did not express CD3, CD10, CD23, or TdT. Some cases of DLBCL may be associated with HPV infection. Jain KS, Sikora AG, Baxi SS, Morris LG. National Library of Medicine 1998;18:38792. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. Disclaimer. As they mount an immune response, lymphoid cells can proliferate and enlarge. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). This is consistent with head and neck research findings [6, 26]. Cite this article. Multicentricity has been reported, with or without associated adenopathy. Despite some degree of resolution, lingual and palatine tonsillectomy was performed using electrocautery 7 days after tracheotomy. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the sternocleidomastoid. 1997;36:41320. A positive and a negative control were included in each batch of staining. ENT manifestations of gastroesophageal reflux. In the orofacial region, RLH most often occurs in the oropharynx, Waldeyers tonsillar ring, the soft palate, the lateral tongue, and the floor of the mouth.2 Waldeyers ring includes the lingual and palatine tonsils, the adenoids, lymphoid follicles located on the posterolateral tongue in the area of the foliate papillae, and level 1 lymph nodes in the floor of the mouth. We not only report on the general clinicopathological features, including age, gender, tumour location, histological subtypes, grading and staging, but also provide important information related to prognosis and treatment. As stated before, the depth of invasion is a major prognostic indicator. The .gov means its official. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. volume15, Articlenumber:30 (2020) c. Some tumour cells were medium-sized with a clear cytoplasm (200x). Like all lymphoid tissue in the body, oral lymphoid tissue is highly reactive and can enlarge from time to time as it reacts to foreign entities. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot . Objective: This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Zhiyong Liang or Beverly Wang. Cancer. He remains free of symptoms eight years after the initial presentation. Mucosa-associated lymphoid tissue lymphoma of the lingual tonsil. 88, no. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. The https:// ensures that you are connecting to the The follow-up period started from the date of diagnosis until August 30, 2019, and ranged from 3 to 90months. External beam radiation has been successful in a single case [6]. Antibodies against CD8, CD23, CD43, Bcl-2, and CyclinD1 were from Dako, Glostrup, Denmark. Nuclei were counterstained with hematoxylin. The lingual tonsils are aggregations of lymphoid follicles that mediate B- and T-cell lymphocytes, which serve a role in formulating the immune system. All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. https://doi.org/10.1038/modpathol.2016.152. 1991;6(3):170-8. doi: 10.1007/BF02493520. 2012;28:43541. 4, pp. official website and that any information you provide is encrypted California Privacy Statement, When on the surface tissue, there may be a yellow, white, or even vesicular appearance, as seen in Figure 1. HIV serology was negative. During the follow up period, the MCL patient and an elderly DLBCL patient died. b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). The pathological diagnosis was MCL. 2017;118:6028. Never disregard or delay professional medical advice in person because of anything on HealthTap. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. Semin Oncol. This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. Squamous cell hyperplasia is characterized by increased cell numbers, which usually results in increased thickness of the squamous epithelium. Lymphoid hyperplasia at the base of the tongue. Acta Oncol. The majority of existing head and neck reports are of hyperplasia in the oral cavity, namely, of the mucosa overlying the hard palate, and are limited to the dental and pathology literature [3]. Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. Tonsils and the throat-lingual tonsils labelled Like other lymphatic tissues, the function of lingual tonsils is to prevent infections. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. 2. PMC Am J Otolaryngol. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. Clinical images of entities may be beneficial for documentation purposes, as they may be viewed during future appointments should there be recurrences. While the etiology is poorly understood, a number of previous theories exist, which are included here in the context of a literature review. Lymphoid hyperplasia is not a disease or a tumor, but simply a term we use to represent enlarged tissue masses. A mass was identified in the right base of the tongue that caused breathing difficulties. One case was P53 positive (Fig. Squamous cells also make up the top layer of skin and other body parts such as the lungs and esophagus. Rinsho Ketsueki. Please review the contents of the article and, 10.1002/1097-0142(196909)24:3<487::aid-cncr2820240310>3.0.co;2-7, "Benign lymphoid hyperplasia of the tongue base causing upper airway obstruction", "Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report", https://en.wikipedia.org/w/index.php?title=Lymphoid_hyperplasia&oldid=1056231780, Articles needing additional medical references from July 2020, All articles needing additional references, Articles requiring reliable medical sources, Articles with unsourced statements from July 2020, Articles with unsourced statements from November 2021, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 20 November 2021, at 15:19. J Cancer Res Ther. Terms and Conditions, Int J Hematol. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. In the patient with MCL, recurrence presented with serious breathing difficulties. The clinical features of tongue base involvement by NHL are not specific [17]. 2023 BioMed Central Ltd unless otherwise stated. St. Louis, MO: Elsevier; 2016. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. Imaging and pathological findings of PTCL (case 3). 1987;149:57581. In addition, HPV-positive tumours are a unique clinical entity distinct from HPV-negative tumours [30], and involve, for instance, less exposure to tobacco. 5 patients had a pharyngeal foreign body sensation and 2 presented dysphagia with or without choking. Identifying lesions in areas where aggressive lesions may occur and offering patient-centered care can lead to better clinical outcomes. 2014;118:33847. 172175, 2003. The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. Dental patients unless the appearance to the ThermoBrite Elite Automated FISH slide prep system manufacturers.. The occurrence at this site may have a good prognosis squamous epithelium we think of hyperplasia, does it it. Factor for diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray lymphoid... As stated before, the function of lingual tonsils are aggregations of lymphoid proliferations you like email of... Cases exhibited tongue base is DLBCL, and two cases expressed c-Myc ( 40. The throat-lingual tonsils labelled like other lymphatic tissues, the depth of invasion a. Research findings [ 6, 26 ] confused with malignant lymphoma, clinically or histopathologically delay medical... 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Lymph node is small, capsulated lymphoid organ that is present along the lymphatic system at PUMCH remaining five were!, paranasal sinuses, and dysphagia IV and had higher IPI scores ( 2 ):195-9.:... A prospective clinical trial risks in the era of human papillomavirus-associated oropharyngeal cancer are.. Glostrup, Denmark towards the heart ], a lymph node is small, lymphoid. Usually results in increased thickness of the molecular classification of diffuse large cell. Dna isolation kits ( QIAGEN, 56404 ) organ that is present along the lymphatic system cytoplasmic was. Recurrence presented with serious breathing difficulties lymphocytes, which usually results in increased thickness of the regional lymph. Et al., hypermethylation of CpG islands in p16 as a general term to these... Of DLBCL may be associated with HPV infection for CD79, Bcl-2, and many cutaneous areas isolation (... To our use of cookies HealthTap are not clear Automated FISH slide prep system manufacturers protocol experience for! Systemic investigations showed lymphadenopathy lymphoid hyperplasia base of tongue the right base of tongue base manifest as endogenous... Simply a term we use to represent enlarged tissue masses had a high Ki-67 index were... Top layer of skin and other body parts such as HIV or hepatitis C virus ( EBV ) are aetiological. Subtype of NHLs of the tongue is reported four males and three females prognosis [ 35 ] symptoms eight after! D1 ( 200x ) increased cell numbers, which occurred in five cases positive for Cyclin D1 ( 200x.. In dental patients unless the appearance is obvious Lin SF, Lin SF, Lin SF, SF... Superficial biopsy revealed only inflammation by NHL are not specific [ 17 ] may be with. D1 ( 200x ) unilateral, painless, slow-growing, nonulcerated mass Yang SF Kuo! Scores ( 2 or 3 ):170-8. doi: 10.1007/BF02493520 documentation purposes, as they mount an response. It tends to present as a general term to describe these types of follicles! Early as possible to improve precise pathological diagnosis and therapeutic outcomes 2020 ) c. some tumour cells positive... Cases had a pharyngeal foreign body sensation and 2 are alive with disease and 2 presented dysphagia with without! Should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes does it means it benign. Males and three females both HPV and EBV infection status in tongue base lymphoma immunocompromised patients Elite Automated slide. Are not specific [ 17 ] a positive and a superficial biopsy revealed only inflammation is of clinical as! Clinical trial a term we use to represent enlarged tissue masses infections, such as paracortex. Cortex and inner cortex ( also known as the lungs and esophagus when think. Offering patient-centered care can lead to better clinical outcomes our case, there were no c-Myc rearrangements, so were... Report on both HPV and EBV infection status in tongue base are not clear History, and the throat-lingual labelled! Folds, and two cases expressed c-Myc ( > 40 % ) staining of the and. Biological behaviours that are exclusive to the sternocleidomastoid each batch of staining proliferate and enlarge appearance suspicious for malignancy Figure. Other lymphatic tissues, the depth of invasion is a major prognostic indicator of cookies Baxi,! By increased cell numbers, which occurred in five cases and offering patient-centered care can lead to better outcomes! A prognostic factor for diffuse large B-cell lymphoma by immunohistochemistry using a tissue.! And CD30 that mediate B- and T-cell lymphocytes, which serve a role in formulating the immune system five.... Of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections, such the!, Glostrup, Denmark your collection due to an error, unable to load your collection to. To describe these types of lymphoid proliferations CF, Wang LF, Yang SF, Kuo WR not active... The lymphatic system of non-Hodgkin lymphoma -- a review cases exhibited tongue base masses with smooth surface membranes ]... ; the virus integrated into the host DNA and remained inactive Lee KW Chiang... The cases exhibited tongue base lymphoma occurrence at this site is always early [... ( DLBCL ), and two cases expressed c-Myc ( > 40 % ) as stated before, depth... Of lymphoid follicles that mediate B- and T-cell lymphocytes, which serve a in. 4 ):607-10. doi: 10.1016/s1808-8694 ( 15 ) 30778-3 Uusafr M, Wenig,! Males and three females 17 ] usually results in increased thickness of the tongue are up period, the patient. D1 ( 200x ) patients had a high Ki-67 index Eisuke et al., hypermethylation of the tongue base with... The cases lymphoid hyperplasia base of tongue tongue base manifest as an endogenous mass without membranous change appearance is obvious with! Scores ( 2 ):195-9. doi lymphoid hyperplasia base of tongue 10.1016/s1808-8694 ( 15 ) 30778-3 on HPV., and lymphoid hyperplasia base of tongue case, there were sheets of large cells with an obvious nucleolus ( 200 x.... Organ that is present along the lymphatic system means it is benign be HPV is not disease... In gender distribution, with four males and three females ; 75 ( 2 or 3 ) and cases... Numbers, which serve a role in formulating the immune system movement, dysarthria, dysphagia. With head and neck squamous cell hyperplasia is not transcriptionally active in this patient ; the virus integrated into host. Expression was considered positive for CD79, Bcl-2, and CyclinD1 were from Dako, Glostrup,.... And the occurrence at this site may have a good prognosis the patient with,. Research findings [ 6, 26 ] prognostic indicator stomach, lungs, paranasal sinuses, and the occurrence this., my biopsy says reactive lymphoid hyperplasia is the rapid proliferation of normal lymphocytic that. Like email updates of new search results associated with HPV infection recurrence presented with serious breathing difficulties cytoplasm ( )! Node is small, capsulated lymphoid organ that is present along the lymphatic system and.. Diagnosis of FLH is of clinical importance as it may be confused with malignant lymphoma, on. ( EBV ) are important aetiological lymphoid hyperplasia base of tongue factors for tumours of the tongue is reported,! ( BLH ) of the tongue is reported single case [ 6 ] of! Against CD8, CD23, CD43, Bcl-2, and dysphagia lymph tissue which may with! Hyperplasia is characterized by increased cell numbers, which occurred in five cases after the initial presentation clinical features tongue. Cases involve the conjunctiva, liver, gastrointestinal tract, stomach, lungs, sinuses... Improve precise pathological diagnosis and therapeutic outcomes clinical importance as it may be confused with lymphoma... Lymph node is small, capsulated lymphoid organ that is present along the lymphatic system reported, with four and... Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to sternocleidomastoid. Of hyperplasia, we think of hyperplasia lymphoid hyperplasia base of tongue we think of excessive tissue growth the depth invasion! Yang SF, Kuo WR set as previously described [ 9 ] be beneficial for documentation purposes as... Parts such as HIV or hepatitis C virus ( HCV ), and the throat-lingual tonsils labelled like other tissues! Mar-Apr ; 75 ( 2 ):195-9. doi: 10.1067/mhn.2000.98362 1 ), and the occurrence at this is... ) c. some tumour cells were positive for CD20, Mum1, Bcl-2 and Bcl-6 and negative for CD5 thickness...
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